Ophthalmology · 1996
Combined corticosteroid and catecholamine stimulation of aqueous humor flow.
Клиническое исследованиеСтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Jacob E, FitzSimon J S, Brubaker R F
Аннотация
PURPOSE: Epinephrine is known to stimulate aqueous humor flow in humans. Corticosteroids are known to augment the effect of beta-adrenergic agonists on the ciliary body. This experiment was carried out to determine whether a corticosteroid can increase the stimulatory effect of epinephrine on aqueous humor flow.
METHODS: Twenty human volunteers were studied for 24 hours. Hydrocortisone was given orally and epinephrine was given intravenously during sleep while aqueous flow was monitored. Flow was compared with a second 24-hour study when oral and intravenous placebos were given. The sequence of administration was randomized. Subjects and investigators were masked. The flows also were compared with a previously published study in which the same dose of epinephrine was administered without steroid.
RESULTS: Epinephrine plus hydrocortisone compared with placebos increased aqueous flow 42% in subjects during sleep. The combination of epinephrine and hydrocortisone was a more potent stimulus to aqueous flow than epinephrine alone, which increased aqueous flow by only 27% (P = 0.045).
CONCLUSION: The two major hormones of the adrenal gland work in concert to increase the rate of aqueous humor flow in humans.
METHODS: Twenty human volunteers were studied for 24 hours. Hydrocortisone was given orally and epinephrine was given intravenously during sleep while aqueous flow was monitored. Flow was compared with a second 24-hour study when oral and intravenous placebos were given. The sequence of administration was randomized. Subjects and investigators were masked. The flows also were compared with a previously published study in which the same dose of epinephrine was administered without steroid.
RESULTS: Epinephrine plus hydrocortisone compared with placebos increased aqueous flow 42% in subjects during sleep. The combination of epinephrine and hydrocortisone was a more potent stimulus to aqueous flow than epinephrine alone, which increased aqueous flow by only 27% (P = 0.045).
CONCLUSION: The two major hormones of the adrenal gland work in concert to increase the rate of aqueous humor flow in humans.
Предметные рубрики MeSH
Administration, OralAdrenergic beta-AgonistsAdultAnti-Inflammatory AgentsAqueous HumorBlood PressureCiliary BodyDouble-Blind MethodDrug CombinationsDrug SynergismEpinephrineFemaleFluorophotometryHeart RateHumansHydrocortisoneInjections, IntravenousIntraocular PressureMaleMiddle AgedTonometry, Ocular