[The inhibiting effect of glycyrrhizin on proliferation of the mice submandibular gland fibrosarcoma cell line in vitro].

OBJECTIVE

To study the inhibiting effect of glycyrrhizin on proliferation of the cell line of mice submandibular gland fibrosarcome in vitro.

METHODS

Light and electronic microscope examination, proliferative state of cells and cycle phase analysis were used.

RESULTS

Administration of glycyrrhizin above 600 mg/L could inhibit cell proliferation, and the effect was dose and time dependent. The morphological change of the cell line affected by glycyrrhizin could be seen with light and electronic microscope. Cell cycle phase analysis showed gLy-cyrrhizin gould stop cells shifting from G1 to S phase.

CONCLUSION

The Lowest inhibition concentration of glycyrrhizin to the cell line was above 600 mg/L, The antineoplastic effect of glycyrrhizin was possibly accomplished by interfering metabolism of G1 phase cells or/and blocking initiation of DNA synthesis.