Pediatric blood & cancer · 2011
MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: a Children's Oncology Group (COG) study.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Sam Thien N, Kersey John H, Linabery Amy M, Johnson Kimberly J, Heerema Nyla A, Hilden Joanne M, Davies Stella M, Reaman Gregory H, Ross Julie A
Аннотация
BACKGROUND: Infant leukemias have a high frequency of mixed lineage leukemia (MLL) gene rearrangements.
PROCEDURE: Using data from a large etiologic study, we evaluated the distribution of selected demographic factors among 374 infant leukemia cases by leukemic subtype, MLL status and diagnosis age.
RESULTS: Overall, 228 cases were MLL+. Compared to white infants, black infants were significantly less likely to have MLL+ leukemia. Further, there was a statistically significantly higher age at diagnosis for infants with t(9;11) translocations compared to all other translocation partners in both acute lymphoblastic leukemia and acute myeloid leukemia cases.
CONCLUSION: These patterns may provide important etiological insight into the biology of infant leukemia.
PROCEDURE: Using data from a large etiologic study, we evaluated the distribution of selected demographic factors among 374 infant leukemia cases by leukemic subtype, MLL status and diagnosis age.
RESULTS: Overall, 228 cases were MLL+. Compared to white infants, black infants were significantly less likely to have MLL+ leukemia. Further, there was a statistically significantly higher age at diagnosis for infants with t(9;11) translocations compared to all other translocation partners in both acute lymphoblastic leukemia and acute myeloid leukemia cases.
CONCLUSION: These patterns may provide important etiological insight into the biology of infant leukemia.