Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 2001
Adenomatous ductal proliferation of the salivary gland.
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Yu G Y, Donath K
Аннотация
OBJECTIVE: The objective of this study is to report a series of patients with adenomatous ductal proliferation of the salivary gland and to investigate the nature and histogenesis of this process.
STUDY DESIGN: The histologic and immunohistochemical studies of 13 patients with adenomatous ductal proliferation of the salivary gland were performed.
RESULTS: Ten cases coexisted with other diseases, such as salivary gland tumor or chronic parotitis. Most of the lesions were limited to 1 or 2 lobules and showed prominent ductal proliferation with some acinar cell complexes. The proliferative ducts had a compact growth pattern with little stroma. Dedifferentiation of acinar cells, identified by the loss of their secretory granules and appearing similar to intercalated duct epithelium, was seen in the early stages of adenomatous ductal proliferation.
CONCLUSION: Acinar cells play a role in the histogenesis of salivary gland tumors because acinar cells clearly participate in the formation of the proliferative ducts.
STUDY DESIGN: The histologic and immunohistochemical studies of 13 patients with adenomatous ductal proliferation of the salivary gland were performed.
RESULTS: Ten cases coexisted with other diseases, such as salivary gland tumor or chronic parotitis. Most of the lesions were limited to 1 or 2 lobules and showed prominent ductal proliferation with some acinar cell complexes. The proliferative ducts had a compact growth pattern with little stroma. Dedifferentiation of acinar cells, identified by the loss of their secretory granules and appearing similar to intercalated duct epithelium, was seen in the early stages of adenomatous ductal proliferation.
CONCLUSION: Acinar cells play a role in the histogenesis of salivary gland tumors because acinar cells clearly participate in the formation of the proliferative ducts.
Предметные рубрики MeSH
AdenolymphomaAdenomaAdenoma, PleomorphicAdolescentAdultCarcinoma, Acinar CellCarcinoma, Adenoid CysticCell DifferentiationCell DivisionChronic DiseaseEpithelial CellsFemaleHumansHyperplasiaImmunohistochemistryMaleMelanomaMiddle AgedParotid NeoplasmsParotitisSalivary DuctsSecretory VesiclesSubmandibular Gland Neoplasms