Revista medica de Chile · 2005
[Clinical and molecular features of cardial gastric cancer associated to Epstein Barr virus].
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Corvalán Alejandro, Akiba Suminori, Valenzuela María Teresa, Cumsille Miguel Angel, Koriyama Chihaya, Argandoña Jorge, Backhouse Claudia, Bal Matilde, Mena Fernando, Palma Mariana, Eizuru Yoshito
Аннотация
BACKGROUND: Mortality caused by cardial gastric cancer in Chile, is increasing. Previously we demonstrated an association between Epstein Barr virus and this specific location of gastric cancer.
AIM: To perform a clinical and molecular characterization of cardial gastric cancer associated to Epstein Barr virus.
MATERIAL AND METHODS: Epstein Barr virus was identified in 93 cardial gastric tumors, by in situ hybridization. Clinical and pathological features, survival and expression of p53 and c-erbB2 were compared between tumors with or without the presence of the virus.
RESULTS: Twenty two (23.6%) tumors expressed Epstein Barr virus. No difference in sex or age of patients with tumors positive or negative for the virus was observed. Epstein Barr positive tumors had a tendency to have a higher frequency of Bormann III endoscopic appearance and a lower frequency of p53 accumulation (p=0.06). Five years survival was 67% and 42% of tumors positive and negative for the presence of the virus, respectively (p=0.57).
CONCLUSIONS: Our results, although not significant, show a tendency towards unique characteristics of cardial gastric tumors associated to Epstein Barr.
AIM: To perform a clinical and molecular characterization of cardial gastric cancer associated to Epstein Barr virus.
MATERIAL AND METHODS: Epstein Barr virus was identified in 93 cardial gastric tumors, by in situ hybridization. Clinical and pathological features, survival and expression of p53 and c-erbB2 were compared between tumors with or without the presence of the virus.
RESULTS: Twenty two (23.6%) tumors expressed Epstein Barr virus. No difference in sex or age of patients with tumors positive or negative for the virus was observed. Epstein Barr positive tumors had a tendency to have a higher frequency of Bormann III endoscopic appearance and a lower frequency of p53 accumulation (p=0.06). Five years survival was 67% and 42% of tumors positive and negative for the presence of the virus, respectively (p=0.57).
CONCLUSIONS: Our results, although not significant, show a tendency towards unique characteristics of cardial gastric tumors associated to Epstein Barr.