Journal of gastroenterology · 2007
A case of lymphoepithelioma-like carcinoma of the colon with ulcerative colitis.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Kojima Yasuyuki, Mogaki Masatoshi, Takagawa Ryo, Ota Ikuko, Sugita Mitsutaka, Natori Shiho, Hamaguchi Yohei, Kurosawa Haruki, Fukushima Tadao, Masui Hidenobu, Fukazawa Shingo, Yamanaka Shoji, Tsuura Yukio, Nagahori Kaoru
Аннотация
Follow-up colonoscopy of a 25-year-old Japanese man with ulcerative colitis (UC) who had undergone endoscopic mucosal resection twice for early colon cancers revealed the presence of a new 1.5-cm-diameter tumor in the sigmoid colon. It was diagnosed by preoperative biopsy as a poorly differentiated adenocarcinoma. Sigmoidectomy was performed, and the pathological findings revealed lymphoepithelioma-like carcinoma (LEC). In situ hybridization to detect Epstein-Barr virus (EBV)-encoded small RNAs showed positive signals in stromal lymphocytes, but weak signals in the tumor cells. The association between EBV and LEC was obscure in this case. Unlike typical UC-mediated colon cancers, the lesion was poorly differentiated, and negative for p53 signals immunohistochemically. These findings may hint at a novel mechanism of carcinogenesis in UC-mediated colorectal cancer.