Thorax · 2020
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Marks Michelle, Steele Chad, Moore Wendy C, Meyers Deborah A, Rector Brian, Ampleford Elizabeth, Bleecker Eugene R, Hastie Annette T
Аннотация
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) reportedly promotes, or conversely, resolves inflammation in asthma. In this study of TRAIL and cell receptors in sputum, bronchoalveolar lavage and biopsy from subjects in the Severe Asthma Research Program at Wake Forest, the high TRAIL group had significant increases in all leucocytes, and was associated with increased type 1, type 2 and type 17 cytokines, but not type 9 interleukin 9. Two variants at loci in the TRAIL gene were associated with higher sputum levels of TRAIL. Increased TRAIL decoy receptor R3/DcR1 was observed on sputum leucocytes compared with death receptor R1/DR4, suggesting reduced apoptosis and prolonged cellular inflammation.
Предметные рубрики MeSH
AdultAsthmaBiopsyBronchiBronchoalveolar Lavage FluidCross-Sectional StudiesCytokinesFemaleForced Expiratory VolumeHumansInflammationLeukocyte CountLeukocytesMaleMiddle AgedPolymorphism, Single NucleotideRespiratory MucosaSeverity of Illness IndexSputumTNF-Related Apoptosis-Inducing LigandTumor Necrosis Factor Decoy ReceptorsVital CapacityYoung Adult