Zhonghua bing li xue za zhi = Chinese journal of pathology · 2015
[Fluorescence in-situ hybridization as a diagnostic tool for cutaneous melanoma].
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Su Jing, Liu Jianying, Zheng Jie, You Jiangfeng, Ma Xiaolong, Zhang Yan, Zhang Jing, Liao Songlin
Аннотация
OBJECTIVE: To explore the utility of fluorescence in situ hybridization as a diagnostic tool for cutaneous melanoma.
METHODS: Twenty cutaneous melanomas and 20 cutaneous nevi from pathology files were selected and analyzed by Vysis melanoma FISH probe kit targeting 3 loci on chromosome 6 (MYB, CEP6 and RREB1) and 1 locus on 11q (CCND1) and data were interpreted based on the Abbott criteria provided by the kit.
RESULTS: Informative FISH results were obtained in 16 melanomas and 18 nevi. Chromosomal aberrations were detected in 12 of the 16 melanomas and only 1 of 18 nevi.
CONCLUSION: FISH is a useful diagnostic tool and able to distinguish cutaneous nevus from melanoma with good sensitivity and specificity.
METHODS: Twenty cutaneous melanomas and 20 cutaneous nevi from pathology files were selected and analyzed by Vysis melanoma FISH probe kit targeting 3 loci on chromosome 6 (MYB, CEP6 and RREB1) and 1 locus on 11q (CCND1) and data were interpreted based on the Abbott criteria provided by the kit.
RESULTS: Informative FISH results were obtained in 16 melanomas and 18 nevi. Chromosomal aberrations were detected in 12 of the 16 melanomas and only 1 of 18 nevi.
CONCLUSION: FISH is a useful diagnostic tool and able to distinguish cutaneous nevus from melanoma with good sensitivity and specificity.