Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2018
Uptake-release by MSCs of a cationic platinum(II) complex active in vitro on human malignant cancer cell lines.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Rimoldi Isabella, Coccè Valentina, Facchetti Giorgio, Alessandri Giulio, Brini Anna Teresa, Sisto Francesca, Parati Eugenio, Cavicchini Loredana, Lucchini Giorgio, Petrella Francesco, Ciusani Emilio, Pessina Augusto
Аннотация
In this study, the in vitro stability of cisplatin (CisPt) and cationic platinum(II)-complex (caPt(II)-complex) and their in vitro activity (antiproliferative and anti-angiogenic properties) were investigated against three aggressive human tumor cell lines. caPt(II)-complex shown a high stability until 9 days of treatment and displayed a significant and higher activity than CisPt against both NCI-H28 mesothelioma (19.37 ± 9.57 μM versus 34.66 ± 7.65 μM for CisPt) and U87 MG glioblastoma (19.85 ± 0.97 μM versus 54.14 ± 3.19 for CisPt). Mesenchymal Stromal Cells (AT-MSCs) showed a significant different sensitivity (IC50 = 71.9 ± 15.1 μM for caPt(II)-complex and 8.7 ± 4.5 μM for CisPt) to the antiproliferative activity of caPt(II)-complex and CisPt. The ability of MSCs to uptake both the drugs in a similar amount of 2.49 pM /cell, suggested a possible development of new therapies based on cell mediated drug delivery.