American journal of obstetrics and gynecology · 2008
Altered responsiveness of small uterine arteries in women with idiopathic menorrhagia.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Mints Miriam, Luksha Leonid, Kublickiene Karolina
Аннотация
OBJECTIVE: This study was undertaken to study vascular reactivity of small myometrial arteries in women with idiopathic menorrhagia.
STUDY DESIGN: Small myometrial arteries were isolated from 6 patients with idiopathic menorrhagia and 4 controls. The contractile responses to thromboxane mimetic (U46619) and endothelin-1 were assessed before and after incubation with N(w)-nitro-L arginine methyl ester alone or in combination with indomethacin (Indo). Endothelium-dependent dilation to bradykinin and basal tension were compared before and after incubation with N(w)-nitro-L arginine methyl ester alone, or with N(w)-nitro-L arginine methyl ester in combination with indomethacin.
RESULTS: Constriction to endothelin-1 was enhanced in idiopathic menorrhagia arteries (P < .05). Idiopathic menorrhagia arteries demonstrated enhanced basal tension after incubation with N(w)-nitro-L arginine methyl ester, which was further exaggerated by indomethacin. NOS inhibition had no effect on basal tension in controls, but basal tension was enhanced after inhibition of cyclooxygenase-derived products (P < .05). Bradykinin-mediated dilation was significantly increased in idiopathic menorrhagia (P < .05).
CONCLUSION: The presence of functional alterations in small myometrial arteries could contribute to idiopathic menorrhagia.
STUDY DESIGN: Small myometrial arteries were isolated from 6 patients with idiopathic menorrhagia and 4 controls. The contractile responses to thromboxane mimetic (U46619) and endothelin-1 were assessed before and after incubation with N(w)-nitro-L arginine methyl ester alone or in combination with indomethacin (Indo). Endothelium-dependent dilation to bradykinin and basal tension were compared before and after incubation with N(w)-nitro-L arginine methyl ester alone, or with N(w)-nitro-L arginine methyl ester in combination with indomethacin.
RESULTS: Constriction to endothelin-1 was enhanced in idiopathic menorrhagia arteries (P < .05). Idiopathic menorrhagia arteries demonstrated enhanced basal tension after incubation with N(w)-nitro-L arginine methyl ester, which was further exaggerated by indomethacin. NOS inhibition had no effect on basal tension in controls, but basal tension was enhanced after inhibition of cyclooxygenase-derived products (P < .05). Bradykinin-mediated dilation was significantly increased in idiopathic menorrhagia (P < .05).
CONCLUSION: The presence of functional alterations in small myometrial arteries could contribute to idiopathic menorrhagia.
Предметные рубрики MeSH
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidAdultBiopsy, NeedleCase-Control StudiesFemaleHumansIndomethacinMenorrhagiaMiddle AgedMuscle, Smooth, VascularMyometriumNG-Nitroarginine Methyl EsterProbabilityReference ValuesRisk AssessmentSensitivity and SpecificityTissue Culture TechniquesUterusVasoconstriction