Klinika oczna · 2006
[The influence of stimulation dopaminergic D, i D2 receptors in lateral geniculate body on flash visual evoked potentials (FVEP) in rats].
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Plech Agata R, Herba Ewa, Pojda-Wilczek Dorota, Makowiecka-Obidzińska Katarzyna, Pojda Stefan M, Plech Andrzej
Аннотация
PURPOSE: The topic of this paper is to define the influence of stimulation dopaminergic D1 i D2 receptors in lateral geniculate body by flash visual evoked potentials (FVEP).
MATERIAL AND METHODS: Wistar rats were examined. There were stereotaxically implanted with guide caniula into the lateral geniculate body to inject substances and with VEPs electrodes on the skull and on the surface of visual cortex. VEPs curve before and after injection into the lateral geniculate body: 0.9% NaCl, agonists of dopamine receptors D1 - SKF 38393, and D2 Quinpirole and also the same agonist after antagonists D1 - SCH 23390, i D2 Sulpiride were analyzed.
RESULTS: Stimulating receptors D1 in the lateral geniculate body cause amplitude increase and shortness of latency. Quinpirole, agonist of D2 receptor do not significant change FVEPs curve.
CONCLUSIONS: Stimulation of D1 receptors in the lateral geniculate body can improve visual transmission throught it and response in the occipital cortex.
MATERIAL AND METHODS: Wistar rats were examined. There were stereotaxically implanted with guide caniula into the lateral geniculate body to inject substances and with VEPs electrodes on the skull and on the surface of visual cortex. VEPs curve before and after injection into the lateral geniculate body: 0.9% NaCl, agonists of dopamine receptors D1 - SKF 38393, and D2 Quinpirole and also the same agonist after antagonists D1 - SCH 23390, i D2 Sulpiride were analyzed.
RESULTS: Stimulating receptors D1 in the lateral geniculate body cause amplitude increase and shortness of latency. Quinpirole, agonist of D2 receptor do not significant change FVEPs curve.
CONCLUSIONS: Stimulation of D1 receptors in the lateral geniculate body can improve visual transmission throught it and response in the occipital cortex.