Feedback from human posterior parietal cortex enables visuospatial category representations as early as primary visual cortex.

INTRODUCTION

Categorization is a fundamental cognitive process, whereby the brain assigns meaning to sensory stimuli. Previous studies have found category representations in prefrontal cortex and posterior parietal cortex (PPC). However, these higher-order areas lack the fine-scale spatial representations of early sensory areas, and it remains unclear what mechanisms enable flexible categorization based on fine-scale features.

METHODS

In this study, we decoded functional MRI signals and measured causal influences, across visual, parietal, and prefrontal cortex from participants performing categorization based on coarse- or fine-scale spatial information in thirteen healthy adults.

RESULTS

We show that category information based on coarse discriminations was represented in the PPC, in the intraparietal sulcus region, IPS1/2, at an early stage of categorization trials, whereas representations of category information based on fine-scale discriminations formed later during interactions between IPS1/2 and primary visual cortex (V1). Specifically, when fine-scale discriminations were necessary, we decoded significant category information from V1 at an intermediate stage of trials and again from IPS1/2 at a late stage. IPS1/2 feedback was critical, because categorization performance improved as causal influence from IPS1/2 to V1 increased. Further, these mechanisms were plastic, as the selectivity of IPS1/2 and V1 responses shifted markedly with retraining to categorize the same stimuli into two new groups.

CONCLUSIONS

Our findings suggest that reentrant processing between the PPC and visual cortex enables flexible abstraction of category information.