Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2006
Sequential analysis of cadherin expression in a 4-year-old girl with intracranial ependymoma.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Yokoi Kentaro, Akiyama Masaharu, Yanagisawa Takaaki, Takahashi-Fujigasaki Junko, Yokokawa Yuichi, Mikami-Terao Yoko, Fukuoka Kohei, Fujisawa Kohji, Nakazaki Hiromichi, Oi Shizuo, Eto Yoshikatsu, Yamada Hisashi
Аннотация
INTRODUCTION: Cadherins are Ca(2+)-dependent cell-to-cell adhesion molecules that play an important role in tissue construction and morphogenesis in multicellular organisms. Cadherin involvement in tumor metastasis has recently been reported.
CASE REPORT: We investigated the expression of E-cadherin and N-cadherin in paraffin-embedded sequential surgical specimens and autopsy specimens from a 4-year-old girl with recurrent ependymoma, subsequent to cerebrospinal fluid (CSF) dissemination. We observed low expression of E-cadherin in all surgical specimens and autopsy specimens. In contrast, expression of N-cadherin was high in all surgical specimens, but was decreased in autopsy specimens.
CONCLUSION: Decreased expression of N-cadherin may be associated with CSF dissemination and may serve as a useful marker for CSF dissemination in patients with intracranial ependymoma.
CASE REPORT: We investigated the expression of E-cadherin and N-cadherin in paraffin-embedded sequential surgical specimens and autopsy specimens from a 4-year-old girl with recurrent ependymoma, subsequent to cerebrospinal fluid (CSF) dissemination. We observed low expression of E-cadherin in all surgical specimens and autopsy specimens. In contrast, expression of N-cadherin was high in all surgical specimens, but was decreased in autopsy specimens.
CONCLUSION: Decreased expression of N-cadherin may be associated with CSF dissemination and may serve as a useful marker for CSF dissemination in patients with intracranial ependymoma.