Respiratory medicine · 2025
Minimal clinically important difference for quadriceps maximal voluntary contraction following pulmonary rehabilitation in people with interstitial lung disease.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Reina-Gutiérrez Sara, Paixão Cátia, Rebelo Patrícia, Antão Joana, Fernandes Vânia, Ferreira Pedro G, Marques Alda
Аннотация
BACKGROUND: Skeletal muscle loss has a devastating effect on daily lives of people with interstitial lung disease (ILD). Pulmonary rehabilitation (PR) improves muscle strength; however, the lack of cut-off values to define clinical improvement limits the interpretability of the obtained gains.
OBJECTIVE: To estimate the minimal clinically important difference (MCID) for quadriceps maximal voluntary contraction (QMVC) in people with ILD, assessed with hand-held dynamometry as an absolute value in kilogram-force (KgF) and as percentage of the predicted value (% pred), after PR in people with ILD.
METHODS: A secondary analysis of data from three previous studies was conducted. Participants took part in a 12-week community-based PR programme. The MCIDs were computed using anchor- and distribution-based methods. Anchors explored were the 1-min sit-to-stand (1-min STS) test, the 6-min walking distance, handgrip strength, modified Medical Research Council questionnaire, St. George's Respiratory Questionnaire and Functional Assessment of Chronic Illness Therapy-Fatigue Subscale. The pooled MCIDs were computed using the weighted arithmetic mean (2/3 anchor and 1/3 distribution-based methods).
RESULTS: Fifty-nine people with ILD (61 % female, 66 ± 11years) were included in the analysis. The 1-min STS test was the only anchor fitting the criteria. There were significant improvements after PR in the QMVC (mean difference = 3.9 ± 8.2 KgF and median difference = 10.9 [1.6; 22.0] % pred, p < 0.001) and 1-min STS test (mean difference = 6.6 ± 7.1 repetitions, p < 0.001). The pooled MCIDs were 3.2 KgF and 10.6 % pred.
CONCLUSION: An increase of at least 3.2 KgF or 10.6 % pred for QMVC in people with ILD after PR represents clinically relevant improvements.
OBJECTIVE: To estimate the minimal clinically important difference (MCID) for quadriceps maximal voluntary contraction (QMVC) in people with ILD, assessed with hand-held dynamometry as an absolute value in kilogram-force (KgF) and as percentage of the predicted value (% pred), after PR in people with ILD.
METHODS: A secondary analysis of data from three previous studies was conducted. Participants took part in a 12-week community-based PR programme. The MCIDs were computed using anchor- and distribution-based methods. Anchors explored were the 1-min sit-to-stand (1-min STS) test, the 6-min walking distance, handgrip strength, modified Medical Research Council questionnaire, St. George's Respiratory Questionnaire and Functional Assessment of Chronic Illness Therapy-Fatigue Subscale. The pooled MCIDs were computed using the weighted arithmetic mean (2/3 anchor and 1/3 distribution-based methods).
RESULTS: Fifty-nine people with ILD (61 % female, 66 ± 11years) were included in the analysis. The 1-min STS test was the only anchor fitting the criteria. There were significant improvements after PR in the QMVC (mean difference = 3.9 ± 8.2 KgF and median difference = 10.9 [1.6; 22.0] % pred, p < 0.001) and 1-min STS test (mean difference = 6.6 ± 7.1 repetitions, p < 0.001). The pooled MCIDs were 3.2 KgF and 10.6 % pred.
CONCLUSION: An increase of at least 3.2 KgF or 10.6 % pred for QMVC in people with ILD after PR represents clinically relevant improvements.