Annals of hematology · 2021
Nivolumab discontinuation and retreatment in patients with relapsed or refractory Hodgkin lymphoma.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Fedorova Liudmila V, Lepik Kirill V, Mikhailova Natalia B, Kondakova Elena V, Zalyalov Yuri R, Baykov Vadim V, Babenko Elena V, Kozlov Andrey V, Moiseev Ivan S, Afanasyev Boris V
Аннотация
Immune checkpoint inhibitors (ICI) have demonstrated high therapeutic efficacy in relapsed or refractory classical Hodgkin lymphoma (r/r cHL). Nevertheless, despite the accumulated data, the question of the ICI therapy duration and efficacy of nivolumab retreatment remains unresolved. In this retrospective study, in a cohort of 23 adult patients with r/r cHL who discontinued nivolumab in complete response (CR), the possibility of durable remission achievement (2-year PFS was 55.1%) was demonstrated. Retreatment with nivolumab has demonstrated efficacy with high overall response rate (ORR) and CR (67% and 33.3% respectively). At the final analysis, all patients were alive with median PFS of 16.5 months. Grade 3-4 adverse events (AEs) were reported in 36% of patients, and there was no deterioration in terms of nivolumab retreatment-associated complications.