Cancer cell · 2014
Hematogenous metastasis of ovarian cancer: rethinking mode of spread.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Pradeep Sunila, Kim Seung W, Wu Sherry Y, Nishimura Masato, Chaluvally-Raghavan Pradeep, Miyake Takahito, Pecot Chad V, Kim Sun-Jin, Choi Hyun Jin, Bischoff Farideh Z, Mayer Julie Ann, Huang Li, Nick Alpa M, Hall Carolyn S, Rodriguez-Aguayo Cristian, Zand Behrouz, Dalton Heather J, Arumugam Thiruvengadam, Lee Ho Jeong, Han Hee Dong, Cho Min Soon, Rupaimoole Rajesha, Mangala Lingegowda S, Sehgal Vasudha, Oh Sang Cheul, Liu Jinsong, Lee Ju-Seog, Coleman Robert L, Ram Prahlad, Lopez-Berestein Gabriel, Fidler Isaiah J, Sood Anil K
Аннотация
Ovarian cancer has a clear predilection for metastasis to the omentum, but the underlying mechanisms involved in ovarian cancer spread are not well understood. Here, we used a parabiosis model that demonstrates preferential hematogenous metastasis of ovarian cancer to the omentum. Our studies revealed that the ErbB3-neuregulin 1 (NRG1) axis is a dominant pathway responsible for hematogenous omental metastasis. Elevated levels of ErbB3 in ovarian cancer cells and NRG1 in the omentum allowed for tumor cell localization and growth in the omentum. Depletion of ErbB3 in ovarian cancer impaired omental metastasis. Our results highlight hematogenous metastasis as an important mode of ovarian cancer metastasis. These findings have implications for designing alternative strategies aimed at preventing and treating ovarian cancer metastasis.
Предметные рубрики MeSH
AnimalsCarcinoma, Ovarian EpithelialCell Line, TumorCell MovementCell ProliferationFemaleHumansMiceMice, Inbred C57BLMice, NudeNeoplasm InvasivenessNeoplasms, Glandular and EpithelialNeoplastic Cells, CirculatingNeuregulin-1OmentumOvarian NeoplasmsParabiosisPeritoneal NeoplasmsRNA InterferenceReceptor, ErbB-3Signal TransductionTime FactorsTransfectionXenograft Model Antitumor Assays