Plasmacytoma and plasma cell myeloma affecting the jaws: A multi-institutional collaborative study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Souza Lucas Lacerda de, Cáceres Cinthia Verónica Bardález López de, Vargas Pablo Agustin, Lopes Márcio Ajudarte, Santos-Silva Alan Roger, Silva Wagner Gomes da, Prado-Ribeiro Ana Carolina, Brandão Thais Bianca, Pereira Juliana, Mesquita Ricardo Alves, Pontes Flávia Sirotheau Correa, González-Arriagada Wilfredo Alejandro, Pedraza Ricardo Martinez, Andrade Bruno Augusto Benevenuto de, Romañach Mario José, Soares Ciro Dantas, Carvalho Maria Goretti Freire de, Pires Fabio Ramôa, Carlos Roman, Fonseca Felipe Paiva, Pontes Hélder Antônio Rebelo, de Almeida Oslei Paes
Аннотация
METHODS: Paraffin-embedded tissue blocks of patients microscopically diagnosed with plasma cell neoplasms in the jaws were retrieved from five pathology files. Data including clinical, radiographic, microscopic and immunohistochemical findings, treatment employed and follow-up status were retrieved from the pathology reports.
RESULTS: Fifty-two cases were retrieved (mean age: 59.4 years) without sex predilection. The mandible was the most affected site (67.3%), usually associated with pain and/or paresthesia (53.8%). Lesions in other bones besides the jaws were reported for 24 patients (46.2%). Radiographically, tumours usually presented as poorly defined osteolytic lesions with unilocular or multilocular images, while microscopy revealed diffuse proliferation of neoplastic plasma cells with nuclear displacement and abundant eosinophilic cytoplasm. Two cases were classified as anaplastic, and amyloid deposits were found in two other cases. Immunohistochemistry was positive for plasma cell markers and negative for CD20 and CD3, and monoclonality for kappa light chain predominated. The overall survival rate after 5 years of follow-up was 26.6%.
CONCLUSION: Plasma cell neoplasms are aggressive tumours with a poor prognosis and involvement of the jaws may be the first complaint of the patient. Thus, oral pathologists, head and neck surgeons and dentists should be aware of their clinical, radiographic and microscopic manifestations.