Consensus Recommendations for the Diagnosis of Vitreoretinal Lymphoma.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Carbonell Denise, Mahajan Sarakshi, Chee Soon-Phaik, Sobolewska Bianka, Agrawal Rupesh, Bülow Tanja, Gupta Vishali, Jones Nicholas P, Accorinti Massimo, Agarwal Mamta, Batchelor Tracy, Biswas Jyotirmay, Cimino Luca, tenDam-van Loon Ninette H, de-la-Torre Alejandra, Frenkel Shahar, Pe'er Jacob, Kramer Michal, Miserocchi Elisabetta, Mochizuki Manabu, Ness Thomas, Rosenbaum James T, Sen H Nida, Simion Michael, Sitter Helmut, Vasconcelos-Santos Daniel V, Habot-Wilner Zohar, Coupland Sarah E, Pulido José S, Smith Justine, Thorne Jennifer E, Zierhut Manfred, Study Group for Vitreoretinal Lymphoma Diagnostics
Аннотация
METHODS: Literature was reviewed for reports supporting the diagnosis of VRL. A questionnaire (Delphi 1 round) was distributed to 28 participants. In the second round (Delphi 2), items of the questionnaire not reaching consensus (75% agreement) were discussed to finalize the recommendations.
RESULTS: Presenting symptoms include floaters and painless loss of vision, vitreous cells organized into sheets or clumps. Retinal lesions are usually multifocal creamy/white in the outer retina. Other findings include retinal lesions with "leopard-skin" appearance and retinal pigment epithelium atrophy. Severe vitreous infiltration without macular edema is the most likely presentation. Diagnostic vitrectomy should be performed. Systemic corticosteroid should be discontinued at least 2 weeks before surgery. An interleukin (IL)-10:IL-6 ratio > 1, positive mutation for the myeloid differentiation primary response 88 gene and monoclonality are indicators of VRL. Multi-modal imaging (optical coherence tomography, fundus autofluorescence) are recommended.
CONCLUSIONS: A consensus meeting allowed the establishment of recommendations important for the diagnosis of VRL.