Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2000
[The efficacy of L-asparaginase in the treatment of refractory midline peripheral T-cell lymphoma].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Yong W, Zhang Y, Zheng W
Аннотация
OBJECTIVE: To improve the treatment outcome of refractory midline peripheral T-cell lymphoma (MPTCL).
METHOD: Eleven patients with refractory MPTCL received salvage chemotherapy consisting of L-asparaginase(L-ASP), vincristine and dexamethosone (L-ASP group), and 10 patients received combined chemotherapy without L-ASP(control group). The response rates and 2 year survival rates were observed.
RESULTS: Response rates were 63.6% for L-ASP group and 10.0% for control group (P < 0.05), and 2 year survival rates were 45.5% and 0 (P < 0.05), respectively. The major side effects of L-ASP were leukocytopenia, elevation of serum bilirubin and hyperglycemia.
CONCLUSION: The L-ASP-based salvage chemotherapy improved the response rate and 2 year survival rate of the patients with refractory MPTCL.
METHOD: Eleven patients with refractory MPTCL received salvage chemotherapy consisting of L-asparaginase(L-ASP), vincristine and dexamethosone (L-ASP group), and 10 patients received combined chemotherapy without L-ASP(control group). The response rates and 2 year survival rates were observed.
RESULTS: Response rates were 63.6% for L-ASP group and 10.0% for control group (P < 0.05), and 2 year survival rates were 45.5% and 0 (P < 0.05), respectively. The major side effects of L-ASP were leukocytopenia, elevation of serum bilirubin and hyperglycemia.
CONCLUSION: The L-ASP-based salvage chemotherapy improved the response rate and 2 year survival rate of the patients with refractory MPTCL.