MedElevator Войти в исследования
← Поиск публикаций

DOI 10.1002/dad2.70444

Медицинская библиотека · Alzheimer's & dementia (Amsterdam, Netherlands) · 2026

Life's Essential 8™ and incident dementia in an urban cohort: Findings from the Northern Manhattan Study.

Gallop Erin-Leigh, Kondeti Pooja, Gardener Hannah, Rundek Tatjana, Gutierrez Jose, Elkind Mitchell S V, Wright Clinton B, Levin Bonnie, Wang Lily, Agudelo Christian, Assuras Stephanie, Guzman Vanessa, Elfassy Tali

СтатьяПеревод пока не подготовлен

Аннотация

INTRODUCTION

The American Heart Association's Life's Essential 8™ (LE8) defines cardiovascular health (CVH) using eight behavioral and clinical metrics. We examined the association between CVH and incident dementia.

METHODS

We used data from 920 dementia-free participants of the Northern Manhattan Study. LE8 scores (range: 0-100) were calculated from information on clinical and behavioral characteristics. Dementia was adjudicated by expert clinicians using neuropsychological assessments and clinical records. We used Cox proportional hazards models to determine associations adjusting for age, sex, race/ethnicity, education, and insurance.

RESULTS

Mean age was 64 years, 60% of participants were female, 65% were Hispanic, and mean LE8 score was 60. Over 9 years, 175 participants developed dementia. Each 10-unit decrement in LE8 score was associated with a greater risk of dementia (hazard ratio [HR]: 1.33; 95% confidence interval [CI]: 1.17-1.51).

DISCUSSION: CVH is important for brain health, and our results support interventions aimed at improving CVH for prevention of dementia.

Для цитирования: Gallop Erin-Leigh, Kondeti Pooja, Gardener Hannah, Rundek Tatjana, Gutierrez Jose, Elkind Mitchell S V, Wright Clinton B, Levin Bonnie, Wang Lily, Agudelo Christian, Assuras Stephanie, Guzman Vanessa, Elfassy Tali. Life's Essential 8™ and incident dementia in an urban cohort: Findings from the Northern Manhattan Study.. Alzheimer's & dementia (Amsterdam, Netherlands). 2026. DOI: 10.1002/dad2.70444.
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.