European journal of nutrition · 2025
Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project.
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Santucci Claudia, Natale Arianna, Pelucchi Claudio, Bonzi Rossella, Lunet Nuno, Morais Samantha, Vioque Jesús, González-Palacios Sandra, Aragonés Nuria, Castaño-Vinyals Gemma, Malekzadeh Reza, Pakseresht Mohammadreza, Negri Eva, Boffetta Paolo, Camargo M Constanza, Curado Maria Paula, Zhang Zuo-Feng, Boccia Stefania, La Vecchia Carlo, Rossi Marta
Аннотация
PURPOSE: The evidence regarding the role of vitamin D on gastric cancer (GC) is controversial. Within the Stomach cancer Pooling (StoP) Project, a global consortium of epidemiological studies on GC, we aimed to evaluate the relationship between dietary vitamin D and GC risk.
METHODS: Five case-control studies were included in the analysis, accounting for 1875 cases and 5899 controls. Odds ratios (OR) of GC and the corresponding 95% confidence intervals (CI) for tertiles of vitamin D intake were computed using logistic regression models adjusted for relevant confounders, including energy intake. The pooled ORs were computed using random-effect models.
RESULTS: The pooled OR of GC for the highest compared to the lowest tertile of vitamin D intake was 1.06 (95% CI 0.80-1.39), with a p for heterogeneity of 0.019. No significant association was found across strata of sex, age, socioeconomic status, smoking status, alcohol intake, and vegetable and fruit consumption.
CONCLUSIONS: Our pooled analysis indicates that there is no association between dietary vitamin D and the risk of GC.
METHODS: Five case-control studies were included in the analysis, accounting for 1875 cases and 5899 controls. Odds ratios (OR) of GC and the corresponding 95% confidence intervals (CI) for tertiles of vitamin D intake were computed using logistic regression models adjusted for relevant confounders, including energy intake. The pooled ORs were computed using random-effect models.
RESULTS: The pooled OR of GC for the highest compared to the lowest tertile of vitamin D intake was 1.06 (95% CI 0.80-1.39), with a p for heterogeneity of 0.019. No significant association was found across strata of sex, age, socioeconomic status, smoking status, alcohol intake, and vegetable and fruit consumption.
CONCLUSIONS: Our pooled analysis indicates that there is no association between dietary vitamin D and the risk of GC.