Head & neck · 2012
New genetic findings in parotid gland pleomorphic adenomas.
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Wemmert Silke, Willnecker Vivienne, Brunner Christian, Wenzel Gentiana Ioana, Sauter Birgit, Meinelt Heike, Bartholmé Nadia, Saada Carolin, Bohle Rainer Maria, Urbschat Steffi, Schick Bernhard
Аннотация
BACKGROUND: Despite numerous studies, the tumor biology of pleomorphic adenomas, the most common salivary gland tumors, is still not completely defined. In order to identify further candidate genes important for tumor biology of pleomorphic adenomas, extended cytogenetic and molecular analysis are mandatory.
METHODS: We performed a detailed molecular cytogenetic analysis using comparative genomic hybridization (CGH) followed by fluorescence in situ hybridization (FISH) with probes for chromosome X, 16p, 17, and 20 on a large cohort of pleomorphic adenomas (n = 29).
RESULTS: We could confirm previously described deletions in pleomorphic adenomas affecting 16p, 17, 20q, and 22 by FISH and/or CGH analysis. Moreover, our CGH study revealed novel candidate regions on 8p23.1pter, 9p, 10q25.1q25.3, and 11q24qter in the series of analyzed pleomorphic adenomas.
CONCLUSION: Our present study reveals new insights in novel candidate regions implicated in pleomorphic adenoma tumorigenesis which should be considered in further molecular studies.
METHODS: We performed a detailed molecular cytogenetic analysis using comparative genomic hybridization (CGH) followed by fluorescence in situ hybridization (FISH) with probes for chromosome X, 16p, 17, and 20 on a large cohort of pleomorphic adenomas (n = 29).
RESULTS: We could confirm previously described deletions in pleomorphic adenomas affecting 16p, 17, 20q, and 22 by FISH and/or CGH analysis. Moreover, our CGH study revealed novel candidate regions on 8p23.1pter, 9p, 10q25.1q25.3, and 11q24qter in the series of analyzed pleomorphic adenomas.
CONCLUSION: Our present study reveals new insights in novel candidate regions implicated in pleomorphic adenoma tumorigenesis which should be considered in further molecular studies.
Предметные рубрики MeSH
Adenoma, PleomorphicAdultAgedCarcinogenesisChromosome AberrationsCohort StudiesCytogenetic AnalysisFemaleGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseGenomicsGermanyHumansIn Situ Hybridization, FluorescenceMaleMiddle AgedParotid NeoplasmsPreoperative CareSalivary Gland NeoplasmsSensitivity and Specificity