Journal of biomedical optics · 2021
Improved sensitivity roll-off in dual reference, buffered spectral-domain optical coherence tomography.
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Otuya David O, Verma Yogesh, Luu Romain, Farrrokhi Hamid, Tearney Guillermo J
Аннотация
SIGNIFICANCE: While spectral-domain optical coherence tomography (SD-OCT) is a preferred form of OCT imaging, sensitivity roll-off limits its applicability for certain biomedical imaging applications.
AIM: The aim of this work is to extend the imaging range of conventional SD-OCT systems for imaging large luminal organs such as the gastrointestinal tract.
APPROACH: We present an SD-OCT system operating at a center wavelength of 1300 nm that uses two delayed reference arms to reduce sensitivity roll-off and an optical switch and a fiber optic delay line to ensure that the interference spectra are acquired from the same sample time window.
RESULT: The proposed system was used to image swine colon ex vivo and duodenum in vivo, demonstrating improved image quality due to a ∼14 dB increase in sensitivity at the edges of the ranging depth.
CONCLUSION: The proposed system requires modest hardware implementation and is compatible with catheter-based endoscopic helical scanning with enhanced sensitivity for the samples at a distance of ∼6 mm from the zero delay point.
AIM: The aim of this work is to extend the imaging range of conventional SD-OCT systems for imaging large luminal organs such as the gastrointestinal tract.
APPROACH: We present an SD-OCT system operating at a center wavelength of 1300 nm that uses two delayed reference arms to reduce sensitivity roll-off and an optical switch and a fiber optic delay line to ensure that the interference spectra are acquired from the same sample time window.
RESULT: The proposed system was used to image swine colon ex vivo and duodenum in vivo, demonstrating improved image quality due to a ∼14 dB increase in sensitivity at the edges of the ranging depth.
CONCLUSION: The proposed system requires modest hardware implementation and is compatible with catheter-based endoscopic helical scanning with enhanced sensitivity for the samples at a distance of ∼6 mm from the zero delay point.