Improving Spatial Resolution and Selectivity of Transcorneal Electrical Stimulation by Temporal Interference Technology.

Transcorneal electrical stimulation (TES) used in a therapeutic device has been demonstrated significant neuroprotective effect for rescuing retinal function. However, the diffuse electric field induced by conventional TES devices reduced their spatial resolution and selectivity, limiting their capability of actively stimulating a severely diseased retina. A cutting-edge neuromodulation approach named temporal interference stimulation (TIS) was reported to induce electric fields focalizing on local neuronal targets. Despite the competent feasibility of application in retinal TIS, the interpretation of characteristics of spatial resolution and selectivity under TIS remains rudimentary. In this study, we conduct in silico investigations to understand the characteristics of spatial selectivity and resolution using a finite element model of a multi-layered eyeball and multiple electrode configuration. By simulating different metrics of electric potentials envelope modulated by TIS, our model supports the possibility of achieving mini-invasive and spatially selective electrical stimulation using retinal TIS. These simulations provide theoretical evidence on the basis of which sophisticated devices for improved spatial selectivity can be designed.Clinical Relevance- This study provides a theoretical basis for understanding how the design of electrode configuration impacts transcorneal TIS performance. This model can guide future development of transcorneal TIS configurations and stimulation strategies that may benefit patients with inherited retinal diseases.