The reabsorption of creatinine from the rabbit bladder.

Using a radioisotope technique the reabsorption of creatinine from normal, inflamed and chronically obstructed bladders of rabbits was investigated. The reabsorption of creatinine from normal bladders was minimal. Chronic obstruction lead to a rise of the reabsorption rate. The most marked reabsorption however was found with the inflamed bladders. This difference of creatinine reabsorption is statistically significant and it was detectable in the 14C-creatinine content of the blood, 14C-creatinine content of the renal pelvis urine and in the activity loss in the bladder urine. The vesical reabsorption of creatinine corresponds in principle with the urea reabsorption which was investigated earlier by the same method. The extent of reabsorption is however different and urea is reabsorbed to a substantially greater extent.