Archives of medical research · 2025
Association Between ACE Gene I/D Polymorphism and Diabetic Retinopathy in Mexican Population.
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Barrera-Perales Karla, Pérez-Cano Héctor, Rojas-Juárez Sergio, Morales-López Oscar, Somilleda-Ventura Alin, Cuevas-Budhart Miguel Angel, Silva Rueda Rogelio Ivan
Аннотация
BACKGROUND AND AIMS: Diabetic retinopathy (DR) is a significant ocular complication. The insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene has been associated with its development.
OBJECTIVE: To evaluate the relationship between the ACE gene I/D polymorphism and the presence of DR to identify the highest-risk allele.
METHODS: 79 patients with diabetic retinopathy and 75 healthy controls were studied. Metabolic and anthropometric measurements were performed, and DNA was extracted to identify the polymorphism using C-reactive protein. Fisher's exact test was used for comparative analysis of allele and genotypic frequencies.
RESULTS: The I/I genotype was more frequent in patients with DR (43%) and was associated with a 3.22-fold increased risk of developing the disease (p = 0.0123). The I allele frequency was 67% in patients and 56% in controls, though no significant difference was found (p = 0.073).
CONCLUSIONS: The higher frequency of the I/I genotype in patients with DR suggests that this genotype may be a risk factor for developing the disease in patients with type 2 diabetes (T2DM). Further studies are recommended to confirm these findings.
OBJECTIVE: To evaluate the relationship between the ACE gene I/D polymorphism and the presence of DR to identify the highest-risk allele.
METHODS: 79 patients with diabetic retinopathy and 75 healthy controls were studied. Metabolic and anthropometric measurements were performed, and DNA was extracted to identify the polymorphism using C-reactive protein. Fisher's exact test was used for comparative analysis of allele and genotypic frequencies.
RESULTS: The I/I genotype was more frequent in patients with DR (43%) and was associated with a 3.22-fold increased risk of developing the disease (p = 0.0123). The I allele frequency was 67% in patients and 56% in controls, though no significant difference was found (p = 0.073).
CONCLUSIONS: The higher frequency of the I/I genotype in patients with DR suggests that this genotype may be a risk factor for developing the disease in patients with type 2 diabetes (T2DM). Further studies are recommended to confirm these findings.