Journal of perinatology : official journal of the California Perinatal Association · 2024
Implementation of an EOS calculator-based protocol decreased infant antibiotic exposure in chorioamnionitis without correlation with placental histopathology.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Robinson Tonya, Knott Kimberly, Liu Zhanxu, Kong Maiying, Telang Sucheta
Аннотация
OBJECTIVE: To determine the impact of the Early Onset Sepsis (EOS) calculator on antibiotic exposure in infants born to mothers with clinical chorioamnionitis and correlate EOS calculator-guided recommendations with placental histopathology.
STUDY DESIGN: Retrospective observational study comparing infants ≥ 36 weeks gestation exposed to maternal clinical chorioamnionitis admitted to the neonatal intensive care unit (NICU) before (Group 1, n = 69) and after (Group 2, n = 139) implementation of an EOS calculator protocol for chorioamnionitis. Infant antibiotic exposure and placental pathology were reviewed. Comparisons were made using Mann-Whitney and chi-square tests.
RESULTS: There was a statistically significant decrease in antibiotic exposure from Group 1 to Group 2 (p < 0.001) with no EOS cases missed. No correlation was found between EOS calculator-based treatment and participant placental histopathology (p = 0.966).
CONCLUSION: Implementation of an EOS calculator protocol specific to our study population reduced antibiotic exposure. No correlations were found between EOS calculator-based antibiotic treatment and histological chorioamnionitis.
STUDY DESIGN: Retrospective observational study comparing infants ≥ 36 weeks gestation exposed to maternal clinical chorioamnionitis admitted to the neonatal intensive care unit (NICU) before (Group 1, n = 69) and after (Group 2, n = 139) implementation of an EOS calculator protocol for chorioamnionitis. Infant antibiotic exposure and placental pathology were reviewed. Comparisons were made using Mann-Whitney and chi-square tests.
RESULTS: There was a statistically significant decrease in antibiotic exposure from Group 1 to Group 2 (p < 0.001) with no EOS cases missed. No correlation was found between EOS calculator-based treatment and participant placental histopathology (p = 0.966).
CONCLUSION: Implementation of an EOS calculator protocol specific to our study population reduced antibiotic exposure. No correlations were found between EOS calculator-based antibiotic treatment and histological chorioamnionitis.