ADMET & DMPK · 2025
Epirubicin-sensitive detection with a CoWO4/reduced graphene oxide modified screen-printed electrode.
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Tajik Somayeh, Moghimian Razieh, Beitollahi Hadi
Аннотация
BACKGROUND AND PURPOSE: Because of its antimetabolic and cytotoxic qualities, epirubicin (EP), a crucial chemotherapeutic drug, has been used to treat a number of cancers, including those of the prostate, breast, ovary, stomach, lung, and colon.
EXPERIMENTAL APPROACH: In this study, CoWO4/reduced graphene oxide (CoWO4/rGO) nanocomposite was synthesised and characterised by field emission-scanning electron microscopy and energy-dispersive X-ray spectroscopy. To provide a novel sensing platform for EP determination, a screen-printed electrode (SPE) surface was modified using the as-fabricated CoWO4/rGO nanocomposite.
KEY RESULTS: Using voltammetric techniques, the electrochemical behaviour of the CoWO4/rGO nanocomposite modified SPE (CoWO4/rGO/SPE) for the EP detection was examined. CoWO4/rGO significantly reduced the overpotential of the EP redox reaction and increased the rate of electron transfer between the electrode and analyte as compared to bare SPE. EP was quantitatively analysed using differential pulse voltammetry.
CONCLUSIONS: It was discovered that the linearity range was 0.01 to 190.0 μM. The sensitivity and limit of detection were 0.1529 μA μM-1 and 0.007 μM, respectively. Additionally, the constructed CoWO4/rGO/SPE sensor's practical applicability was investigated in pharmaceutical samples with good recovery outcomes.
EXPERIMENTAL APPROACH: In this study, CoWO4/reduced graphene oxide (CoWO4/rGO) nanocomposite was synthesised and characterised by field emission-scanning electron microscopy and energy-dispersive X-ray spectroscopy. To provide a novel sensing platform for EP determination, a screen-printed electrode (SPE) surface was modified using the as-fabricated CoWO4/rGO nanocomposite.
KEY RESULTS: Using voltammetric techniques, the electrochemical behaviour of the CoWO4/rGO nanocomposite modified SPE (CoWO4/rGO/SPE) for the EP detection was examined. CoWO4/rGO significantly reduced the overpotential of the EP redox reaction and increased the rate of electron transfer between the electrode and analyte as compared to bare SPE. EP was quantitatively analysed using differential pulse voltammetry.
CONCLUSIONS: It was discovered that the linearity range was 0.01 to 190.0 μM. The sensitivity and limit of detection were 0.1529 μA μM-1 and 0.007 μM, respectively. Additionally, the constructed CoWO4/rGO/SPE sensor's practical applicability was investigated in pharmaceutical samples with good recovery outcomes.