Iranian journal of pathology · 2026
Association of Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) With Molecular Subtypes of Breast Cancer.
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Kumari Pummi, Sinha Ruchi, Ranjan Alok, Ajit Surabhi, Kumar Tarun, Pandey Jagjit Kumar
Аннотация
BACKGROUND & OBJECTIVE: Breast cancer (BC) is the most common cancer and a leading cause of cancer-related deaths among Indian women. Inflammation and the tumor microenvironment have a significant influence on cancer development, progression, immune surveillance, and response to therapy. The neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) are simple, measurable markers of subclinical inflammation. This study aimed to evaluate the association of NLR and PLR with the molecular subtypes and clinicopathological parameters of BC.
METHODS: A hospital-based study was conducted on 228 BC patients. Cases were classified into four molecular subtypes, which were further divided into Group A with a good prognosis (Luminal A and Luminal B) and Group B with a poor prognosis (HER2-enriched and TNBC). Cutoff values for NLR and PLR were calculated using the ROC curve.
RESULTS: The cutoff values for NLR and PLR were 2.64 and 90, respectively. NLR was significantly higher (≥2.64) in TNBC (70.6%) and lower (<2.64) in Luminal A (79.2%). Elevated NLR and PLR were associated with clinical T stage (P=0.005 and P=0.028), high PI (P=0.006 and P=0.029), and advanced stage (P=0.002 and P=0.026). A high PLR (≥90) was observed in 60.3% of advanced BC cases, compared to 39.7% of early BC cases. NLR and PLR were negatively correlated with ER and PR (P<0.05).
CONCLUSION: A significant correlation was observed between high NLR and PLR and adverse prognostic clinico-pathological factors in breast cancer. NLR and PLR could serve as valuable, cost-effective markers for prognosis and prediction in breast cancer.
METHODS: A hospital-based study was conducted on 228 BC patients. Cases were classified into four molecular subtypes, which were further divided into Group A with a good prognosis (Luminal A and Luminal B) and Group B with a poor prognosis (HER2-enriched and TNBC). Cutoff values for NLR and PLR were calculated using the ROC curve.
RESULTS: The cutoff values for NLR and PLR were 2.64 and 90, respectively. NLR was significantly higher (≥2.64) in TNBC (70.6%) and lower (<2.64) in Luminal A (79.2%). Elevated NLR and PLR were associated with clinical T stage (P=0.005 and P=0.028), high PI (P=0.006 and P=0.029), and advanced stage (P=0.002 and P=0.026). A high PLR (≥90) was observed in 60.3% of advanced BC cases, compared to 39.7% of early BC cases. NLR and PLR were negatively correlated with ER and PR (P<0.05).
CONCLUSION: A significant correlation was observed between high NLR and PLR and adverse prognostic clinico-pathological factors in breast cancer. NLR and PLR could serve as valuable, cost-effective markers for prognosis and prediction in breast cancer.