Successful Haploidentical Hematopoietic Stem Cell Transplantation for Chemotherapy-Induced Aplastic Anemia in a Breast Cancer Survivor: A Case Report and Literature Review.

Chemotherapy-induced aplastic anemia (AA) is a rare but potentially life-threatening complication in solid tumor treatment. While allogeneic hematopoietic stem cell transplantation (HSCT) is a recognized treatment for AA, haploidentical HSCT (haplo-HSCT) for chemotherapy-induced AA in solid tumor patient survivors remains largely unexplored. We report a unique case of successful haplo-HSCT in a breast cancer survivor who developed AA following chemotherapy. In addition, we conducted a comprehensive literature review on chemotherapy-induced AA in breast cancer patients and its management, with a focus on HSCT outcomes. This case demonstrates the potential efficacy of haplo-HSCT in treating chemotherapy-induced AA in breast cancer survivors. It highlights an important therapeutic option for this rare but severe complication, particularly when matched donors are unavailable. Our experience contributes valuable insights to the limited literature on managing this challenging clinical scenario.