Zhonghua nan ke xue = National journal of andrology · 2008
[Expression of OCTN2 mRNA in the human epididymis and its significance].
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Gong Dong-Ming, Li Zheng, Zhu Xiao-Bin, Liu Yu-Lin, Cao Xiao-Rong, Liu Yong, Wang Yi-Xin
Аннотация
OBJECTIVE: To explore the mechanism of L-Carnitine transport and the expression of OCTN2 mRNA in the human epididymis so as to provide a theoretical basis for male contraception.
METHODS: We collected specimens from human epididymides and determined the expressions of OCTN2 mRNA in the caput, corpus and cauda of the epididymis by RT-PCR.
RESULTS: OCTN2 mRNA was expressed in the caput, corpus and cauda of the epididymis.
CONCLUSION: The human epididymis may rely on OCTN2 for transporting L-Carnitine into the epididymal duct to promote sperm maturation. With the accumulation of information on OCTN2 in the human epididymis, OCTN2 will become a new molecular target for researches on male contraception.
METHODS: We collected specimens from human epididymides and determined the expressions of OCTN2 mRNA in the caput, corpus and cauda of the epididymis by RT-PCR.
RESULTS: OCTN2 mRNA was expressed in the caput, corpus and cauda of the epididymis.
CONCLUSION: The human epididymis may rely on OCTN2 for transporting L-Carnitine into the epididymal duct to promote sperm maturation. With the accumulation of information on OCTN2 in the human epididymis, OCTN2 will become a new molecular target for researches on male contraception.