European journal of microbiology & immunology · 2025
Epidemiological, clinical and immunological features of Schistosoma spp., Stronglyoides stercoralis and Taenia spp. infections in Ghanaian HIV patients.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Frickmann Hagen, Sarfo Fred Stephen, Norman Betty Roberta, Dompreh Albert, Agyei Martin Kofi, Asibey Shadrack Osei, Boateng Richard, Kuffour Edmund Osei, Di Cristanziano Veronica, Loderstädt Ulrike, Tufa Tafese Beyene, Feldt Torsten, Eberhardt Kirsten Alexandra
Аннотация
BACKGROUND: Interactions of helminth infections and human immunodeficiency virus (HIV) remain incompletely understood. This study aimed to assess the clinical, epidemiological, and immunological characteristics of co-infections involving HIV and selected nematode, trematode and cestode species commonly detected in stool samples.
METHODS: A cross-sectional study was conducted among people-living-with-HIV (PLWH) with and without anti-retroviral therapy and HIV-negative controls at a tertiary hospital in Kumasi, Ghana. Stool samples were analyzed by real-time PCR for the presence of Strongyloides stercoralis, Schistosoma spp. as well as Taenia spp. Diagnostic findings were compared with clinical, demographic, socioeconomic and immunological data.
RESULTS: Low prevalences of helminth infections were observed across the study population, ranging from 1.9% for S. stercoralis to 2.8% for Schistosoma spp. Only weak and infrequent associations were found between helminth infections and HIV status or immunosuppression. Identified risk factors included male sex, younger age, shorter duration since HIV diagnosis, and poor food hygiene in the case of taeniasis.
CONCLUSIONS: In this Ghanaian population, co-infections of HIV and helminths were infrequent and showed limited immunological associations. These findings suggest that helminth detection in PLWH is more likely to reflect local endemicity than HIV-related immunosuppression.
METHODS: A cross-sectional study was conducted among people-living-with-HIV (PLWH) with and without anti-retroviral therapy and HIV-negative controls at a tertiary hospital in Kumasi, Ghana. Stool samples were analyzed by real-time PCR for the presence of Strongyloides stercoralis, Schistosoma spp. as well as Taenia spp. Diagnostic findings were compared with clinical, demographic, socioeconomic and immunological data.
RESULTS: Low prevalences of helminth infections were observed across the study population, ranging from 1.9% for S. stercoralis to 2.8% for Schistosoma spp. Only weak and infrequent associations were found between helminth infections and HIV status or immunosuppression. Identified risk factors included male sex, younger age, shorter duration since HIV diagnosis, and poor food hygiene in the case of taeniasis.
CONCLUSIONS: In this Ghanaian population, co-infections of HIV and helminths were infrequent and showed limited immunological associations. These findings suggest that helminth detection in PLWH is more likely to reflect local endemicity than HIV-related immunosuppression.