European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes · 1983
Effect of prostaglandins E1, E2, and F2 alpha on the electric activity of the sphincter of Oddi in living rabbit.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Martinez E, Sarles J C
Аннотация
The effect of prostaglandins (PGs), i.e. PGE1, PGE2 and PGF2 alpha (0.5-32 micrograms/kg), on the electrical activity of the rabbit sphincter of Oddi was studied in vivo. PGs were injected intravenously as a bolus and electrical activity of the sphincter and the duodenum was recorded before and during 15 min after the injection. Variations in biliary pressure were also studied at the same time. PGE1 strongly decreased the activity of the sphincter and biliary pressure which were both increased by PGF2 alpha. Both PGE1 and PGF2 alpha showed a dose-response curve of Michaelis-Menten type. Unexpectedly PGE2 increased at first then decreased electrical activity but not significantly. These effects appeared very early after intravenous injection and were evident with low doses.