Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae · 2003
[Serum anti-titin antibody in patients with myasthenia gravis].
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Li Yan-feng, Zhang Jun-bao, Cui Li-ying
Аннотация
OBJECTIVE: To study the clinical significance of serum anti-titin antibody level in the diagnosis of myasthenia gravis (MG) with thymoma.
METHOD: The serum anti-titin antibody was analysed by ELISA method in 40 cases of health control group, 90 cases of MG, 17 cases of MG with thymoma and 7 cases of no-MG thymoma. The positive rate was compared among these groups.
RESULTS: The positive rate of anti-titin antibody was significantly higher in MG with thymoma patients than MG patients (94% and 3%, P < 0.01). According to the Osserman's classification, anti-titin antibody was present mostly in patients (43%) in IV stage, and also present in 2 cases of 7 who with no-MG thymoma.
CONCLUSION: Serum anti-titin antibody test is helpful in the diagnosis of MG with thymoma.
METHOD: The serum anti-titin antibody was analysed by ELISA method in 40 cases of health control group, 90 cases of MG, 17 cases of MG with thymoma and 7 cases of no-MG thymoma. The positive rate was compared among these groups.
RESULTS: The positive rate of anti-titin antibody was significantly higher in MG with thymoma patients than MG patients (94% and 3%, P < 0.01). According to the Osserman's classification, anti-titin antibody was present mostly in patients (43%) in IV stage, and also present in 2 cases of 7 who with no-MG thymoma.
CONCLUSION: Serum anti-titin antibody test is helpful in the diagnosis of MG with thymoma.