Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2018
Genome Evolution Analysis of Recurrent Testicular Malignant Mesothelioma by Whole-Genome Sequencing.
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Zhang Shigeng, Zhang Qi, Sun Qing, Tang Jinlong, Chen Jimin, Ji Na, Zheng Yichun, Fang Francia, Lei Wanjun, Li Pengpeng, Zhang Nan
Аннотация
BACKGROUND/AIMS: Malignant mesothelioma of the tunica vaginalis testis is a rare and lethal disease. The genomic characteristics and genetic changes of tumor cells during the progression of this disease are unknown.
METHODS: we performed whole-genome sequencing of four successive tumor samples derived from surgery and a blood sample in a single patient.
RESULTS: All tumors were found to have significant C-to-T and T-to-C mutations, and amplification of copy number in chromosomes 1 and 12 were notified in all tumor samples. Subclone analysis revealed a parallel evolution of the tumor in this patient. We also identified some mutations in mesothelioma-associated genes such as KIF25, AHNAK, and PRDM2.
CONCLUSIONS: The results showed a comprehensive genomic change in malignant mesothelioma of the tunica vaginalis testis and provide a better understanding of the clonal evolution during tumor recurrence and metastasis.
METHODS: we performed whole-genome sequencing of four successive tumor samples derived from surgery and a blood sample in a single patient.
RESULTS: All tumors were found to have significant C-to-T and T-to-C mutations, and amplification of copy number in chromosomes 1 and 12 were notified in all tumor samples. Subclone analysis revealed a parallel evolution of the tumor in this patient. We also identified some mutations in mesothelioma-associated genes such as KIF25, AHNAK, and PRDM2.
CONCLUSIONS: The results showed a comprehensive genomic change in malignant mesothelioma of the tunica vaginalis testis and provide a better understanding of the clonal evolution during tumor recurrence and metastasis.
Предметные рубрики MeSH
AgedAntineoplastic AgentsDNA-Binding ProteinsEvolution, MolecularHistone-Lysine N-MethyltransferaseHumansINDEL MutationKinesinsLung NeoplasmsMaleMembrane ProteinsMesotheliomaMesothelioma, MalignantMutagenesis, InsertionalNeoplasm ProteinsNeoplasm Recurrence, LocalNuclear ProteinsPolymorphism, Single NucleotideRadiation, IonizingSequence Analysis, DNATesticular NeoplasmsTranscription FactorsWhole Genome Sequencing