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Войти в исследования Journal of dermatological science · 2026
N,N-dimethylglycine sodium salt prevents human dermal papilla senescence and promotes hair growth in patients with pattern hair loss.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Mihály Johanna, Lendvai Alexandra, Béke Gabriella, Hollósi Erika, Völker Jörn Michael, Wiesche Erik Schulze Zur, Celleno Leonardo, Tolaini Maria Vittoria, Rossi Alfredo, Ala Lorenzo, Lányi Árpád, Bácsi Attila, Bíró Tamás
Аннотация
BACKGROUND: In our previous studies, N,N-dimethylglycine sodium salt (DMG-Na) was found to exert anti-inflammatory and anti-oxidant effects in human epidermal keratinocytes and promote the synthesis of regenerating growth factors (e.g., vascular endothelial growth factor).
OBJECTIVE: In the current investigation, we assessed the effects of DMG-Na to modulate hair follicle-derived dermal papilla (DP) senescence induced by oxidative (H2O2) or non-oxidative (Bromodeoxyuridine) stimuli using in vitro cultured human DP cells. Further, in two randomized, double-blind, placebo-controlled, parallel-group, sex-stratified in vivo studies, we determined the efficacy of a topical DMG-Na containing formulation on more than three hundred patients with hair loss.
METHODS: In the in vitro arm, intracellular Ca2+ measurements, senescence-associated β-galactosidase determinations, qRT-PCR assays, and various immunolabeling methods were employed whereas multiple hair loss parameters were assessed in the in vivo human studies.
RESULTS: DMG-Na (0.05%) significantly prevented the effects of H2O2 and Bromodeoxyuridine to upregulate the number of SA-β-Gal positive cells. Likewise, DMG-Na significantly normalized the expressions of several upregulated (e.g., matrix metalloproteinases 1 and 3, p21, interleukin-1β, tumor necrosis factor-α) or downregulated (e.g., Ki67, lamin B1, collagens 1A1 and 3A1) senescence-associated markers by the inducers. In line with these anti-senescence effects, in the human trials, topical formulations containing 0.5% DMG-Na significantly improved hair loss parameters.
CONCLUSION: Our findings - together with our prior evidence that topically applied DMG-Na enhanced skin blood flow in humans - collectively suggest that DMG-Na is an effective and promising active for the management of hair conditions characterized by impaired cellular growth, repair, and dysregulated oxidative metabolic status.
OBJECTIVE: In the current investigation, we assessed the effects of DMG-Na to modulate hair follicle-derived dermal papilla (DP) senescence induced by oxidative (H2O2) or non-oxidative (Bromodeoxyuridine) stimuli using in vitro cultured human DP cells. Further, in two randomized, double-blind, placebo-controlled, parallel-group, sex-stratified in vivo studies, we determined the efficacy of a topical DMG-Na containing formulation on more than three hundred patients with hair loss.
METHODS: In the in vitro arm, intracellular Ca2+ measurements, senescence-associated β-galactosidase determinations, qRT-PCR assays, and various immunolabeling methods were employed whereas multiple hair loss parameters were assessed in the in vivo human studies.
RESULTS: DMG-Na (0.05%) significantly prevented the effects of H2O2 and Bromodeoxyuridine to upregulate the number of SA-β-Gal positive cells. Likewise, DMG-Na significantly normalized the expressions of several upregulated (e.g., matrix metalloproteinases 1 and 3, p21, interleukin-1β, tumor necrosis factor-α) or downregulated (e.g., Ki67, lamin B1, collagens 1A1 and 3A1) senescence-associated markers by the inducers. In line with these anti-senescence effects, in the human trials, topical formulations containing 0.5% DMG-Na significantly improved hair loss parameters.
CONCLUSION: Our findings - together with our prior evidence that topically applied DMG-Na enhanced skin blood flow in humans - collectively suggest that DMG-Na is an effective and promising active for the management of hair conditions characterized by impaired cellular growth, repair, and dysregulated oxidative metabolic status.