Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie · 1984
Placental alkaline phosphatase in tumour tissue and serum.
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Mössner E, Pfleiderer G, Dittel K D
Аннотация
Using immunochemical techniques, alkaline phosphatase isoenzymes were determined in tissue samples of breast carcinomas and carcinomas of the gastrointestinal tract. In breast carcinomas only 19% of the patients expressed significant placental alkaline phosphatase activity, compared with 78% in gastrointestinal tumours. The intestinal isoenzyme was found in 50% of the breast carcinomas and in nearly all of the other examined tissues. The two isoenzymes usually represent 1% of the total alkaline phosphatase activity, but in a few cases they may constitute between 10 and 90%. In the serum of the patients under examination, elevated total alkaline phosphatase activity was found in only 7%, and elevated placental alkaline phosphatase in 6% of the cases. No cases of elevated serum intestinal alkaline phosphatase were found. We therefore consider that serum placental alkaline phosphatase is a poor tumour marker for a general screening.