A Rare Case of Cronkhite-Canada Syndrome in a Moroccan Female Patient.

Cronkhite-Canada syndrome (CCS) is a rare nonhereditary disorder characterized by gastrointestinal polyps and ectodermal manifestations, such as alopecia and nail dystrophy. This report highlights the diagnostic and therapeutic challenges of CCS and contributes to the global understanding of the syndrome. A 50-year-old woman presented with persistent anorexia, fatigue, abdominal discomfort, alopecia, and onychodystrophy. Diagnostic evaluation revealed characteristic endoscopic findings of gastrointestinal polyps and histopathological features consistent with CCS. The patient was treated with glucocorticoids, resulting in clinical and nutritional improvement. Nutritional support and immunosuppressive agents may serve as adjunct therapies, but further research is needed to establish definitive guidelines. This case underscores the importance of thorough endoscopic and histopathological evaluations in rare syndromes like CCS. It also emphasizes the significance of early diagnosis and a multidisciplinary approach to disease management.