Fertility and sterility · 2004
A prospective evaluation of the effects of salpingectomy on endometrial lymphocyte clusters in patients with hydrosalpinges.
Клиническое исследованиеСтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Ito Chikako, Ito Masafumi, Itakura Atsuo, Asai Masako, Narita Osamu, Mizutani Shigehiko
Аннотация
OBJECTIVE: To investigate the effect of hydrosalpinges on embryo implantation.
DESIGN: Prospective study.
SETTING: Private fertility and university hospitals.
PATIENT(S): Eighteen patients with unilateral or bilateral hydrosalpinges who underwent salpingectomy.
INTERVENTION(S): Pre- and posttreatment endometrial biopsies for immunohistochemical evaluation.
MAIN OUTCOME MEASURE(S): Pre- and posttreatment lymphocyte populations in endometrial samples, evaluated by immunohistochemical identification.
RESULT(S): Endometrial samples from pretreatment exhibited small lymphocytic clusters of CD3+, CD8+, CD4+, granzyme B positive, and CD56+. After salpingectomy, the numbers of cluster lesions were significantly decreased.
CONCLUSION(S): Because a characteristic distribution of lymphocytes in endometrium with hydrosalpinges was found, activation of T/NK (natural killer) lymphocytes in endometrium might be involved in the impairment of embryo implantation in cases of hydrosalpinges.
DESIGN: Prospective study.
SETTING: Private fertility and university hospitals.
PATIENT(S): Eighteen patients with unilateral or bilateral hydrosalpinges who underwent salpingectomy.
INTERVENTION(S): Pre- and posttreatment endometrial biopsies for immunohistochemical evaluation.
MAIN OUTCOME MEASURE(S): Pre- and posttreatment lymphocyte populations in endometrial samples, evaluated by immunohistochemical identification.
RESULT(S): Endometrial samples from pretreatment exhibited small lymphocytic clusters of CD3+, CD8+, CD4+, granzyme B positive, and CD56+. After salpingectomy, the numbers of cluster lesions were significantly decreased.
CONCLUSION(S): Because a characteristic distribution of lymphocytes in endometrium with hydrosalpinges was found, activation of T/NK (natural killer) lymphocytes in endometrium might be involved in the impairment of embryo implantation in cases of hydrosalpinges.