[Transcriptional activity of EBNA2 through RBP-J].

Epstein-Barr virus (EBV) is consistently associated with a variety of B-cell malignancies including Burkitt lymphoma, post-transplant lymphoma, and central nervous system lymphoma in AIDS. EBV infection in vitro leads to the immortalization of B lymphocytes and the outgrowth of continually proliferating lymphoblastoid cell lines, a process that is dependent on a functional EBV nuclear antigen 2 (EBNA2). EBNA2 is essential for transformation of human primary B-lymphocytes by the EB virus. EBNA2 is a pleiotropic activator of viral and cellular genes and is targeted to DNA by interacting with RBP-J. RBP-J is a novel type of DNA binding nuclear protein which is highly conserved in evolution, and originally isolated by its ability to bind to the Jk-type V (D) J recombination signal sequence. Here we would like to show you the mechanism of EBNA2 through RBP-J, and compare to the interaction of the RBP-J protein with Notch.