Simplified Geriatric Assessment in Older Patients With Diffuse Large B-Cell Lymphoma: The Prospective Elderly Project of the Fondazione Italiana Linfomi.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Merli Francesco, Luminari Stefano, Tucci Alessandra, Arcari Annalisa, Rigacci Luigi, Hawkes Eliza, Chiattone Carlos S, Cavallo Federica, Cabras Giuseppina, Alvarez Isabel, Fabbri Alberto, Re Alessandro, Puccini Benedetta, Barraclough Allison, Delamain Marcia Torresan, Ferrero Simone, Usai Sara Veronica, Ferrari Angela, Cencini Emanuele, Pennese Elsa, Zilioli Vittorio Ruggero, Marino Dario, Balzarotti Monica, Cox Maria Christina, Zanni Manuela, Di Rocco Alice, Lleshi Arben, Botto Barbara, Hohaus Stefan, Merli Michele, Sartori Roberto, Gini Guido, Nassi Luca, Musuraca Gerardo, Tani Monica, Bottelli Chiara, Kovalchuk Sofia, Re Francesca, Flenghi Leonardo, Molinari Annalia, Tarantini Giuseppe, Chimienti Emanuela, Marcheselli Luigi, Mammi Caterina, Spina Michele
Аннотация
METHODS: We conducted the prospective Elderly Project study on patients with DLBCL older than 64 years who underwent our Fondazione Italiana Linfomi original geriatric assessment (oGA) (age, Cumulative Illness Rating Scale for Geriatrics, activities of daily living, and instrumental activities of daily living) before treatment. Treatment choice was left to the physician's discretion. The primary end point was overall survival (OS) (ClinicalTrials.gov identifier: NCT02364050).
RESULTS: We analyzed 1,163 patients (median age 76 years), with a 3-year OS of 65% (95% CI, 62 to 68). Because at multivariate analysis on oGA, age > 80 years retained an independent correlation with OS, we also developed a new, simplified version of the GA (sGA) that classifies patients as fit (55%), unfit (28%), and frail (18%) with significantly different 3-year OS of 75%, 58%, and 43%, respectively. The sGA groups, International Prognostic Index, and hemoglobin levels were independent predictors of OS and were used to build the Elderly Prognostic Index (EPI). Three risk groups were identified: low (23%), intermediate (48%), and high (29%), with an estimated 3-year OS of 87% (95% CI, 81 to 91), 69% (95% CI, 63 to 73), and 42% (95% CI, 36 to 49), respectively. The EPI was validated using an independent external series of 328 cases.
CONCLUSION: The Elderly Project validates sGA as an objective tool to assess fitness status and defines the new EPI to predict OS of older patients with DLBCL.