Leukemia & lymphoma · 2024
Richter transformation - retrospective treatment outcomes analysis in Polish Adult Leukemia Study Group.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Sośnia Oktawia, Pruszczyk Katarzyna, Danecki Michał, Wąsik-Szczepanek Ewa, Tryc-Szponder Jagoda, Iskierka-Jażdżewska Elżbieta, Majeranowski Alan, Krzemień Helena, Bołkun Łukasz, Paszkiewicz-Kozik Ewa, Drozd-Sokołowska Joanna, Kwiatkowski Jacek, Wiśniewska-Organek Dominika, Prochorec-Sobieszek Monika, Szumera-Ciećkiewicz Anna, Budziszewska Bożena, Jamroziak Krzysztof, Hus Iwona, Lech-Marańda Ewa, Puła Bartosz
Аннотация
Richter transformation (RT) is defined as developing an aggressive lymphoma in 2-10% of patients suffering from chronic lymphocytic leukemia (CLL). So far, no complex analysis of RT demographics and treatment outcomes has been performed in Poland. Thus, the retrospective analysis of 124 patients with RT from Polish hematology centers was designed. Ninety-nine patients with diffuse large B-cell lymphoma (DLBCL-RT) were identified. The median overall survival (OS) for DLBCL-RT was 17.3 months, while for Hodgkin lymphoma (HL-RT)-21.3 months. In multivariate analysis, the independent factors of worse OS for DLBCL-RT were: prior CLL therapy, ECOG stage ≥2, and elevated serum LDH activity. Patients who proceeded to hematopoietic stem cell transplantation (HSCT) achieved better results. The median OS in allogeneic HSCT recipients was not reached, while in autologous HSCT median OS was 51.3 months. In conclusion, our study represents the largest dataset of patients diagnosed with RT in Poland and confirms its dismal prognosis.