Treating Multiline Treatment Failure in Advanced Colon Cancer Based on Evolutionary Theory: A Case Report.

PURPOSE: Currently, there is no standard regimen for third-line therapy in advanced colon cancer. Intratumoral heterogeneity and tumor evolution have been substantiated in multiple cancer types, paving the way for exploratory research into new treatment strategies for pulmonary metastases from colorectal cancer.

PATIENTS AND

METHODS

In this report, we present a case of advanced colon cancer with lung metastasis. After multiple lines of therapy (including FOLFOX, FOLFIRI combined with targeted therapy) failed, the patient received a lung cancer-derived regimen to colorectal pulmonary metastases through an evolutionary perspective.

RESULTS

After two cycles, the patient achieved partial response (PR), and after eight cycles, the disease was stable (SD), with a good quality of life.

CONCLUSION

The application of a lung cancer-derived regimen to colorectal pulmonary metastases through an evolutionary perspective may offer a new therapeutic direction for patients who have exhausted standard options.