Pathology, research and practice · 2025
Association of vitamin D receptor gene polymorphisms in gastrointestinal cancer: A systematic review and meta-analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод пока не подготовлен
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Wang Hongyu, Yang Yawen, Du Juan
Аннотация
BACKGROUND: Gastrointestinal cancers (GICs), encompassing malignancies of the esophagus, stomach, and colorectal regions, are among the most prevalent cancers worldwide. Given the inconsistent and heterogeneous findings across studies, this meta-analysis aims to comprehensively assess the association between vitamin D receptor (VDR) gene polymorphisms and the risk of GICs.
METHODS: A systematic search was conducted in MEDLINE, Web of Science, Scopus, and Embase to identify relevant studies investigating the association between VDR polymorphisms and GIC risk. After removing duplicates, studies were screened based on predefined inclusion and exclusion criteria. Data analysis was performed using Comprehensive Meta-Analysis software (version 2). Publication bias was evaluated using Egger's test, and study heterogeneity was assessed using the I² statistic. Pooled odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated.
RESULTS: A total of 51 studies were included in the meta-analysis. Significant associations were found between gastric cancer and the FokI polymorphism (ff vs. FF: OR = 1.58; FF+Ff vs. ff: OR = 0.52), as well as the TaqI polymorphism (tt vs. TT: OR = 1.70). For colorectal cancer (CRC), the BsmI variant showed consistent associations in the recessive, heterozygous, and allelic models, even after excluding studies not in Hardy-Weinberg equilibrium. No significant associations were observed for Cdx2 or in relation to esophageal cancer. Subgroup and meta-regression analyses revealed age- and region-specific effects.
CONCLUSION: VDR gene polymorphisms, particularly FokI and TaqI, are significantly associated with gastric cancer risk, while BsmI is linked to increased susceptibility to CRC. No associations were observed for esophageal cancer. These results support the potential role of genetic variants in gastrointestinal carcinogenesis and warrant further validation in diverse populations.
METHODS: A systematic search was conducted in MEDLINE, Web of Science, Scopus, and Embase to identify relevant studies investigating the association between VDR polymorphisms and GIC risk. After removing duplicates, studies were screened based on predefined inclusion and exclusion criteria. Data analysis was performed using Comprehensive Meta-Analysis software (version 2). Publication bias was evaluated using Egger's test, and study heterogeneity was assessed using the I² statistic. Pooled odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated.
RESULTS: A total of 51 studies were included in the meta-analysis. Significant associations were found between gastric cancer and the FokI polymorphism (ff vs. FF: OR = 1.58; FF+Ff vs. ff: OR = 0.52), as well as the TaqI polymorphism (tt vs. TT: OR = 1.70). For colorectal cancer (CRC), the BsmI variant showed consistent associations in the recessive, heterozygous, and allelic models, even after excluding studies not in Hardy-Weinberg equilibrium. No significant associations were observed for Cdx2 or in relation to esophageal cancer. Subgroup and meta-regression analyses revealed age- and region-specific effects.
CONCLUSION: VDR gene polymorphisms, particularly FokI and TaqI, are significantly associated with gastric cancer risk, while BsmI is linked to increased susceptibility to CRC. No associations were observed for esophageal cancer. These results support the potential role of genetic variants in gastrointestinal carcinogenesis and warrant further validation in diverse populations.