British journal of cancer · 2025
Effect of risk-based screening for upper gastrointestinal cancers: a multi-center real-world study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Tian Hongrui, Liu Mengfei, Liu Zhen, Shi Chao, Chen Lei, Zhang Yine, Li Mei, Li Xiaoli, Ma Yincheng, Ma Xiaoming, Liang Yingying, Shi Ruichun, Liu Hongli, Zheng Hongchen, Yang Wenlei, Pan Yaqi, Chen Huanyu, Lv Jinhan, He Zhonghu, Ke Yang
Аннотация
BACKGROUND: To evaluate the feasibility, effectiveness, and cost-effectiveness of risk-based sequential screening for upper gastrointestinal (UGI) cancer via questionnaire-based quantitative models.
METHODS: We applied the risk-based screening strategy to the ongoing government-administered screening project in two areas (Longde and Litong) of Ningxia Hui Autonomous Region, China. Through epidemiological investigation, participants assessed as high-risk were invited for endoscopic screening.
RESULTS: A total of 9492 participants were enroled and completed questionnaire-based assessment, and 2552 (26.89%) participants were evaluated as high-risk. Among the high-risk subjects, 1198 (46.94%) individuals further received endoscopic examination. The detection rate of risk-based screening was 2.28 times as high as that of historical data of universal screening (p = 0.002) (Longde: 2.15% vs. 0.99%; Litong: 1.18% vs. 0.38%), with a similar early detection rate of ~60-70%. The average cost for detecting one case and the average cost for detecting one early case were 30.76% lower (Longde: $12,919 vs. $16,783; Litong: $21,836 vs. $45,512) and 28.99% lower (Longde: $20,993 vs. $24,475; Litong: $30,570 vs. $75,854), respectively, than those for universal screening.
CONCLUSIONS: This real-world, multi-centre study demonstrates that risk-based sequential screening is feasible and cost-effective in detecting UGI cancers, and is expected to be applied in other areas.
METHODS: We applied the risk-based screening strategy to the ongoing government-administered screening project in two areas (Longde and Litong) of Ningxia Hui Autonomous Region, China. Through epidemiological investigation, participants assessed as high-risk were invited for endoscopic screening.
RESULTS: A total of 9492 participants were enroled and completed questionnaire-based assessment, and 2552 (26.89%) participants were evaluated as high-risk. Among the high-risk subjects, 1198 (46.94%) individuals further received endoscopic examination. The detection rate of risk-based screening was 2.28 times as high as that of historical data of universal screening (p = 0.002) (Longde: 2.15% vs. 0.99%; Litong: 1.18% vs. 0.38%), with a similar early detection rate of ~60-70%. The average cost for detecting one case and the average cost for detecting one early case were 30.76% lower (Longde: $12,919 vs. $16,783; Litong: $21,836 vs. $45,512) and 28.99% lower (Longde: $20,993 vs. $24,475; Litong: $30,570 vs. $75,854), respectively, than those for universal screening.
CONCLUSIONS: This real-world, multi-centre study demonstrates that risk-based sequential screening is feasible and cost-effective in detecting UGI cancers, and is expected to be applied in other areas.