[Activity of proliferative and apoptotic processes in the integration of human papillomavirus type 16 DNA into the cervical epithelium].

Sixty 60 human papillomavirus (HPV) type 16-positive cervical epithelium biopsy specimens were studied by cytological, histological, immunomorphological, and PCR assays. No correlation was found between proliferation markers and the degree of integration of HPV 16 DNA integration into the cell genome. The number of cells with Ki-67 expression, mitoses, and their alteration was related to the grade of epithelial lesion. Expression of p53 was detected only in the episomal form of HPV DNA and its low integration.