Steroids · 2021
Apoptosis inducing properties of 3-biotinylate-6-benzimidazole B-nor-cholesterol analogues.
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Zhu Zhiling, Liu Zhiping, Cui Jianguo, Huang Yanmin, Chen Hualong, Wu Yulan, Huang Xiaotong, Gan Chunfang
Аннотация
In this work, a series of Biotin-substituted B-nor-cholesteryl benzimidazole compounds were synthesized. The antiproliferativeactivities of these compounds were evaluated in vitro using a series of human cancer cell lines, including HeLa (cervical cancer), SKOV3 (ovarian cancer), T-47D (thymus gland cancer), MCF-7 (human breast cancer) and HEK293T (normal renal epithelial) cells. These compounds displayed distinct antiproliferative activities against the currently tested cancer cells. The apoptotic properties induced by compound 6d were further investigated. Our results showed that compound 6d could induce the apoptosis of SKOV3 cells, blocking the cell growth in S-phase. Western blotting analyses revealed that compound 6d can induce cell apoptosis via the mitochondria-dependent pathway.