HOXA7 can be used for prognostic evaluation and molecular targeted therapy of gliomas: a multidimensional study based on a large sample size.

HOXA7 has been reported to play an important role in various malignant tumors; however, its role in gliomas has not yet been elucidated. This retrospective study aimed to comprehensively investigate the expression patterns, clinical significance, and potential molecular mechanisms of HOXA7 in gliomas through multi-dimensional analysis. Based on a large sample size of 1946 gliomas from various databases, this study used a variety of statistical and bioinformatics methods to explore the role of HOXA7 in gliomas at multiple levels (mRNA, cell signaling pathways, clinical characteristics, and prognosis). HOXA7 has abnormally high expression in gliomas, and its expression level can be used as an independent prognostic factor for gliomas, as well as having some clinical diagnostic value. In addition, HOXA7 may be involved in the regulation of some cancer-related cell signaling pathways, such as pantothenate and CoA biosynthesis. Abnormally high expression of HOXA7 may be significantly correlated with multiple clinical features and cancer-related cell signaling pathways, and it may be used as a biomarker and molecular target for evaluating prognosis of gliomas.