Retina (Philadelphia, Pa.) · 2025
PRERETINAL HYPERREFLECTIVE DOTS: A Novel Optical Coherence Tomography Sign Associated With the Development of Epiretinal Membrane After Vitrectomy for Rhegmatogenous Retinal Detachment.
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Mhibik Bayram, Bernabei Federico, Pellegrini Marco, Constant Antoine, Azri Cassem, Eymard Pauline, Romeo Maria Angela, Azan Frederic, Giannaccare Giuseppe, Rothschild Pierre-Raphael
Аннотация
PURPOSE: To investigate the association between preretinal hyperreflective dots (PHD) with the occurrence of epiretinal membrane (ERM) after pars plana vitrectomy for rhegmatogenous retinal detachment (RRD).
METHODS: This retrospective study included patients who underwent pars plana vitrectomy for RRD at Ophtalmopôle de Paris. Optical coherence tomography scans were acquired at 1, 3, and 6 months and 1 year postsurgery. Preretinal hyperreflective dots were defined as point-like hyperreflective deposits on the inner retinal surface on the first postoperative optical coherence tomography. The association between PHD and ERM was evaluated using logistic regression and Kaplan-Meier analysis.
RESULTS: Of 894 patients who underwent vitrectomy for RRD, 417 were included in the analysis. Univariate analysis showed significant associations between ERM occurrence and macula-off RRD ( P = 0.043), number of retinal tears ( P = 0.002), use of cryopexy ( P = 0.012), C 2 F 6 tamponade ( P = 0.045), and presence of PHD on optical coherence tomography ( P < 0.001). On multivariate analysis, presence of PHD ( P < 0.001) and use of cryopexy ( P = 0.013) were significant predictors of ERM. Kaplan-Meier analysis indicated that the cumulative probability of developing an ERM at 6 months was 4% in patients without PHD and 26% in patients with PHD ( P < 0.001).
CONCLUSION: Preretinal hyperreflective dots are associated with the occurrence of ERM after vitrectomy for RRD.
METHODS: This retrospective study included patients who underwent pars plana vitrectomy for RRD at Ophtalmopôle de Paris. Optical coherence tomography scans were acquired at 1, 3, and 6 months and 1 year postsurgery. Preretinal hyperreflective dots were defined as point-like hyperreflective deposits on the inner retinal surface on the first postoperative optical coherence tomography. The association between PHD and ERM was evaluated using logistic regression and Kaplan-Meier analysis.
RESULTS: Of 894 patients who underwent vitrectomy for RRD, 417 were included in the analysis. Univariate analysis showed significant associations between ERM occurrence and macula-off RRD ( P = 0.043), number of retinal tears ( P = 0.002), use of cryopexy ( P = 0.012), C 2 F 6 tamponade ( P = 0.045), and presence of PHD on optical coherence tomography ( P < 0.001). On multivariate analysis, presence of PHD ( P < 0.001) and use of cryopexy ( P = 0.013) were significant predictors of ERM. Kaplan-Meier analysis indicated that the cumulative probability of developing an ERM at 6 months was 4% in patients without PHD and 26% in patients with PHD ( P < 0.001).
CONCLUSION: Preretinal hyperreflective dots are associated with the occurrence of ERM after vitrectomy for RRD.