Tropical medicine and infectious disease · 2026
Strongyloides stercoralis Hyperinfection Presenting as Diffuse Alveolar Hemorrhage in an Endemic Region: A Case Report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Motta Juan Camilo, Delgado Manuel Alejandro, Mugnier-Quijano Jacqueline
Аннотация
BACKGROUND: Strongyloides stercoralis is a soil-transmitted helminth capable of establishing chronic infection through an autoinfective cycle, with the potential to progress to life-threatening hyperinfection, particularly in immunocompromised individuals.
CASE PRESENTATION: We report the case of a 70-year-old man from an endemic region in Colombia with metastatic urothelial carcinoma who developed hyperinfection syndrome following corticosteroid therapy for spinal cord compression. The patient presented with progressive respiratory failure and diffuse alveolar hemorrhage. Chest imaging showed bilateral ground glass opacities, and bronchoalveolar lavage revealed numerous larvae consistent with S. stercoralis, confirming the diagnosis. Despite supportive care and broad-spectrum antimicrobial therapy, the patient experienced rapid clinical deterioration and died.
CONCLUSIONS: This case highlights the importance of considering strongyloidiasis in the differential diagnosis of diffuse alveolar hemorrhage in endemic settings, particularly in patients receiving corticosteroids. Early recognition and timely treatment are essential to reduce the high associated mortality. Preventive strategies, including targeted screening or empiric ivermectin administration prior to immunosuppression, should be considered in high-risk populations.
CASE PRESENTATION: We report the case of a 70-year-old man from an endemic region in Colombia with metastatic urothelial carcinoma who developed hyperinfection syndrome following corticosteroid therapy for spinal cord compression. The patient presented with progressive respiratory failure and diffuse alveolar hemorrhage. Chest imaging showed bilateral ground glass opacities, and bronchoalveolar lavage revealed numerous larvae consistent with S. stercoralis, confirming the diagnosis. Despite supportive care and broad-spectrum antimicrobial therapy, the patient experienced rapid clinical deterioration and died.
CONCLUSIONS: This case highlights the importance of considering strongyloidiasis in the differential diagnosis of diffuse alveolar hemorrhage in endemic settings, particularly in patients receiving corticosteroids. Early recognition and timely treatment are essential to reduce the high associated mortality. Preventive strategies, including targeted screening or empiric ivermectin administration prior to immunosuppression, should be considered in high-risk populations.